Immunoregulation in new zealand mice

IFN- Induces Early Lethal Lupus in Preautoimmune (New Zealand Black New Zealand White)F1 but Not in BALB/c Mice

Coote New Zealand Futures Trust New Zealand

On Media A workshop report from US Institute for Peace examined Arab media, August, 05 (http://usip.org/virtual diplomacy/publications/reports/18.html), with special focus on attitudes to US and to the West. The relevant Arab governments play a double role since mostly, they control the media, where they appease the ideological positions of their own threatening insurgencies while focusing publ...

Interleukin 27 inhibits atherosclerosis via immunoregulation of macrophages in mice.

Chronic inflammation in arterial wall that is driven by immune cells and cytokines plays pivotal roles in the development of atherosclerosis. Interleukin 27 (IL-27) is a member of the IL-12 family of cytokines that consists of IL-27p28 and Epstein-Barr virus induced gene 3 (EBI3) and has anti-inflammatory properties that regulate T cell polarization and cytokine production. IL-27-deficient (Ldl...

L chain allelic inclusion does not increase autoreactivity in lupus-prone New Zealand Black/New Zealand White mice.

L chain allelic inclusion has been proposed as a B cell tolerance mechanism in addition to clonal deletion, clonal anergy, and receptor editing. It is said to rescue autoreactive B cells from elimination by diluting out the self-reactive BCR through the expression of a second innocuous L chain. In autoimmune animals, such as lupus-prone mice, allelically included B cells could be activated and ...

Sialoadhesin deficiency does not influence the severity of lupus nephritis in New Zealand Black x New Zealand White F1 mice

INTRODUCTION Systemic lupus erythematosus (SLE) is a chronic inflammatory condition with multisystem involvement. One of the key features of the disease is the upregulation of type I interferons, resulting in the so-called "interferon signature". Recent flow cytometric and transcriptomic studies identified Sialoadhesin (Sn, CD169) as an important interferon-induced blood monocyte biomarker in d...